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KMID : 1103720090610060379
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Journal of the Korean Society of Radiology
2009 Volume.61 No. 6 p.379 ~ p.385
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Different Degree of FDG Uptake of Non-Small Cell Lung Cancer in PET-CT: What Dose It Imply?
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Jung Min-Young
Sun Hyun-Ju
Choi Song
Kim Yun-Hyun
Chong A-Ri
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Abstract
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Purpose: To examine the degree of fluorodeoxyglucose (FDG) uptake in non small cell lung cancers (NSCLCs) and its implications according to the cell type, tumor differentiation, size and stage.
Materials and Methods: From February 2004 to February 2008, 161 patients (117 males, 44 Females) with surgically proven NSCLCs who underwent preoperative FDG positron emission tomography (PET) and curative surgery (stage I-IIIA) were enrolled in this study. The degree of FDG uptake of NSCLCs was evaluated retrospectively by measuring the maximum standard uptake values (max SUVs) in PET-CT according to the cell type, tumor differentiation, size and stage.
Results: Squamous cell carcinomas (SCCs, n=75) had higher max SUVs than the adenocarcinomas (ADCs, n=86) (p<0.01). Poorer tumor differentiation was related to higher max SUVs in ADCs. There was significant difference between the well and poorly differentiated ADCs (p=0.02). Larger tumors tended to have higher max SUVs (p<0.01) in NSCLCs. There were no significant differences between the max SUVs and stages.
Conclusion: SCCs had a higher metabolic rate than ADCs. The higher degree of FDG uptake in ADCs can suggest a poorer tumor grade. Larger tumors have a tendency for higher FDG uptake in NSCLCs.
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KEYWORD
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Lung Neoplasms, Fluorodeoxyglucose F18, Positron-Emission Tomography, Carcinoma, Non-Small-Cell Lung
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